Systemic toxicity

March 20th and 21st 2012, Brussels, Belgium

The European REACH regulations as well as testing bans for cosmetic ingredients in Europe and a possible US TSCA reauthorization mark the desire for transition to an animal-free systemic toxicity testing strategy. Other areas and novel products could similarly benefit from human predictive approaches. A recent stocktaking (Adler et al. 2011, Toxicol 85, 367-485.) and its expert review (Hartung et al. 2011, ALTEX 28, 183-209.) identified gaps in the science available. In order to promote the development of a roadmap to close these gaps, an expert workshop was held (Basketter et al 2012, ALTEX 29:3-89), which was presented and discussed here in a multi-stakeholder forum. Beside CAAT and CAAT-Europe, ecopa, EUSAAT, Doerenkamp-Zbinden-Foundation, ESTIV, IVITIP, ESTIV, IIVS, Humane Society International, ToxCast (US EPA) as well as cefic and Cosmetics Europe hosted this event. This event also benefited from the advisory comments of Eurogroup for Animals and ecopa as well as from the contributions of the SEURAT-1 consortium and the European Chemicals Agency (ECHA).

The public expert responses were constructive and the discussions on the chapter of the recommendations of the presented report were lively. A summary of this event will be published in ALTEX soon.

Please find the Agenda and uploaded talks below!

Agenda:

Tuesday March 20th 2012
10:00-10:40 Welcome notes by Marcel Leist, Introduction ecopa and Eurogroup for Animals
10:40-11:00 “The EU cosmetic regulation as a driver for animal-free systemic toxicity testing”, Dr. Robert Taalman, Cosmetics Europe
11:00-11:20 “Use of non-animal models in regulatory science: Challenges & opportunities in REACH & CLP”, Dr. Derek Knight, ECHA
11:20-11:40 "In vivo Repeated Dose Systemic Toxicity Testing: SEURAT-1", Dr. Tilman Gocht, Eberhard Karls University Tuebingen
11.40-12.00 “US activities for new approaches to systemic toxicity testing”, Dr. Martin Stephens, JHSPH/CAAT/EBTC
13:00-13:30 “Roadmap for animal-free repeated dose testing”, Dr. A. Rossi, CAAT-Europe
13:30-14:30 Discussion on the future of repeated dose testing
14:30-15:00 “Roadmap for reproductive toxicity testing”, Prof. T. Hartung, JHSPH/CAAT/EBTC
15:00-16:00 Discussion on the future of reproductive toxicity testing
16:30-17:00 “Roadmap for animal-free skin sensitization testing”, Dr. G. Maxwell, Unilever
17:00-18:00 Discussion on the future of skin sensitization testing
Wednesday March 21st 2012
09:00-09:30 “Roadmap for animal-free toxicokinetics testing”, Dr. H. Clewell, The Hamner Institute
09:30-10:30 Discussion on future of toxicokinetics testing
11:00-11:30 “Roadmap for carcinogenicity testing” Prof. T. Hartung, JHSPH/CAAT/EBTC
11:30-12:30 Discussion on the future of carcinogenicity testing
13:30-14:00 “Drawing the future roadmap for animal-free toxicity testing”, Prof. M. Leist, University of Konstanz/CAAT
14:00-15:00 Discussions on “The Day after Tomorrow”